SIDEROPHORE-BASED IMMUNIZATION AGAINST GRAM-NEGATIVE BACTERIA

摘要

The present invention provides novel enterobactin-carrier protein conjugates and salmochelin-carrier protein conjugates, such as compounds of Formula (I), and salts thereof. The present invention also provides compositions, kits, and methods that involve the compounds of Formula (I) and are useful in inducing an immune response, treating a bacterial infection and/or inflammatory bowel disease in a subject, preventing a bacterial infection and/or inflammatory bowel disease in a subject, or inhibiting the growth of or killing a bacterium.

主权项

1. A compound of Formula (I):
CP-(L-Ent)n  (I) wherein CP is a carrier protein, L is a linker, Ent is enterobactin or a salmochelin, and n is a number between 1-400, inclusive; or a salt, hydrate, solvate, polymorph, co-crystal, tautomer, stereoisomer, or isotopically labeled derivative thereof.