System And Method For Interactive Patient Specific Simulation Of Radiofrequency Ablation Therapy

摘要

A method and system for interactive patient-specific simulation of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. A computational domain is generated from the patient-specific anatomical model of the liver. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the circulatory system of the liver by solving a bio-heat equation for each node on the level-set representation using a Lattice-Boltzmann method (LBM) implementation. Cellular necrosis in the liver is computed based on the simulated heat diffusion. Visualizations of a computed necrosis region and temperature maps of the liver are generated. A user input is interactively received to modify the position of the virtual ablation probe, the heat diffusion and cellular necrosis is re-simulated based on the user input, and the visualizations of the computed necrosis region and the temperature maps are updated.

主权项

1. A method for interactive patient-specific simulation of liver tumor ablation, comprising:
estimating a patient-specific anatomical model of the liver and venous system of the liver from medical image data of a patient; generating a computational domain from the patient-specific anatomical model of the liver; simulating blood flow in the liver and the circulatory system of the liver based on the patient-specific anatomical model; simulating heat diffusion due to ablation based on a virtual ablation probe position and the simulated blood flow in the liver and the circulatory system of the liver by solving a bio-heat equation at each of a plurality of nodes of the computational domain; and computing cellular necrosis in the liver based on the simulated heat diffusion and updating tissue parameters based on a computed cellular state.