GENETICALLY MODIFIED T CELL RECEPTOR MICE

摘要

The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified non-human animal and methods of making the same. Various methods of using the genetically modified non-human animal are also provided.

主权项

1. A genetically modified non-human animal, comprising in its genome:
an unrearranged human T cell receptor (TCR) α variable gene comprising at least one unrearranged human Vα segment and at least one unrearranged human Jα segment, wherein the unrearranged human TCRα variable gene is operably linked to a non-human TCRα constant gene sequence.