| 主权项 |
1. A method for treating a subject infected with or at risk of infection with Ebola, the method comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound of formula (I) comprising: wherein n is 1 or 2; Ar is phenyl or thienyl, and is optionally substituted; each R1 is independently R6, C(O)R6, C(O)—OR6, or C(O)N(R6)2; R2 is H or optionally substituted C1-C6 alkyl, or a group of formula —C(O)NH—R1; R3 is independently at each occurrence selected from halo, NO2, CN, R, OR, NR2; S(O)qR, COOR, and CONR2, where each R is independently H, C1-C4 alkyl, or C1-C4 haloalkyl; m is 0-4; R4 is R6, halo, =0, COOR6, CON(R6)2, S(O)qR6, N(R6)2, or OR6; p is 0-2; each q is independently 0-2; Z is O or NR5; R5 is R6 or C(O)R6; and R6 is independently at each occurrence selected from H, C1-C6 alkyl, C5-C6 aryl, and (C5-C6-aryl)-C1-C6 alkyl, where each alkyl and aryl is optionally substituted; provided that n is 2 when Z is O and Ar represents para-halophenyl; or a pharmaceutically acceptable salt thereof. |
