| 发明名称 |
CHEMOTHERAPY-RESISTANT IMMUNE CELLS |
| 摘要 |
Embodiments of the disclosure include compositions and methods useful for treating cancers that are sensitive to a chemotherapy, such as temozolomide. The methods allow effective cell immunotherapy to be used with chemotherapy when the cell immunotherapy is susceptible to being rendered ineffective by the chemotherapy. In specific aspects, the cancer is being treated by temozolomide (TMZ) and tumor antigen-specific T-cells that are resistant to TMZ. |
| 申请公布号 |
US2016024175(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201414773416 |
申请日期 |
2014.03.10 |
| 申请人 |
Baylor College of Medicine |
发明人 |
Chow Kevin Kwong-Hon;Yi Zhongzhen;Shaffer Donald R.;Gottschalk Stephen M. G. |
| 分类号 |
C07K14/705;C07K14/725;A61N5/10;A61K38/45;A61K38/17;A61K45/06;C12N9/10;A61K31/4188 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polynucleotide comprising a sequence that encodes O6-methylguanine-DNA methyltransferase (MGMT) and a sequence that encodes a chimeric antigen receptor (CAR). |
| 地址 |
Houston TX US |
