VACCINE

摘要

The disclosure provides immunogenic compositions comprising human picornavirus peptides derived from structural proteins of the virus, constructs comprising the peptides, the peptides themselves and their use in the prevention of picornavirus infection and disease. Particular peptides from VP4 and VP1 are disclosed.

主权项

1. An immunogenic composition comprising:
(a) a first and second peptide derived from structural protein of a picornavirus, said peptides each capable of inducing a cross-neutralising immune response against two or more picornaviruses or picornavirus serotypes; (b) picornavirus peptide consisting of no more than 20 amino acids from the N terminus of VP4, which peptide includes amino acids 1-16 of VP4 or a variant of amino acids 1-16 having 1-4 amino acid additions or deletions at either end and/or 1-2 amino acid substitutions or additions or deletions within the peptide sequence; (c) a picornavirus peptide consisting of amino acids 32-45 from VP1 or a variant of amino acids 32-45 of VP1 having 1-4 amino acid additions or deletions at either end and/or 1-2 amino acid substitutions or additions or deletions within the peptide sequence; and/or (d) a chimeric polypeptide particle comprising a backbone polypeptide capable of forming a particle and at least one peptide comprising an epitope of a picornavirus structural polypeptide; and a pharmaceutically acceptable diluent, excipient or carrier.