Antibodies to IL-6 and use thereof

摘要

Disclosed are therapeutic methods using IL-6 antagonists such as an Ab 1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof Patients will preferably comprise those exhibiting (or atπsk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related proteιn(s), cachexia, fever, weakness and/or fatigue prior to treatment The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others