| 摘要 |
PROBLEM TO BE SOLVED: To provide innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of the p38 MULTI-tRNA synthetase complex.SOLUTION: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. Embodiments of the present invention relate generally to the discovery of protein fragments of aminoacyl-tRNA synthetases (AARSs) and the p38 multi-tRNA complex genes, which possess non-canonical biological activities, such as extracellular signaling activities, and/or other characteristics of therapeutic and diagnostic relevance. |
