| 发明名称 |
METHODS FOR INCREASING EFFICACY OF LIPID FORMULATED siRNA |
| 摘要 |
This invention relates to methods for increasing the efficiency of siRNA administrations via pre-administration of an agent that lowers LDL receptor levels. |
| 申请公布号 |
US2016024498(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201514700938 |
申请日期 |
2015.04.30 |
| 申请人 |
TEKMIRA PHARMACEUTICALS CORPORATION |
发明人 |
Fitzgerald Kevin;Frank-Kamenetsky Maria;Akinc Akin;Maier Martin A. |
| 分类号 |
C12N15/113;A61K31/7088;A61K31/567;A61K9/127;A61K31/366 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for administering a neutral liposomal formulated, siRNA targeting a gene to a subject comprising administering to the subject an agent that increases LDLR levels, and subsequently administering a first effective dose of the neutral liposomal formulated, siRNA targeting a gene, wherein said first effective dose is lower than a dose of the neutral liposomal formulated siRNA administered to the subject without the agent. |
| 地址 |
Burnaby CA |
