| 发明名称 |
LNA ANTISENSE OLIGONUCLEOTIDES FOR THE MODULATION OF MYC EXPRESSION |
| 摘要 |
The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment. |
| 申请公布号 |
US2016024495(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201314378698 |
申请日期 |
2013.02.15 |
| 申请人 |
ENZON PHARMACEUTICALS, INC. ;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
Bandaru Rajanikanth;Zhang Yixian;Qu Zhengxing;Greenberger Lee;Ott Christopher;Bradner James Elliott |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An oligomer of between 10-30 nucleobases in length which comprises a contiguous nucleobase sequence of a total of between 10-16 nucleobases, wherein the continuous nucleobase sequence comprises between 0-2 mismatches to a corresponding region of a sequence selected from the group consisting of:(SEQ ID NO: 5)5′-TTCACCATGTCTCCTC-3′;(SEQ ID NO: 11)5′-GGTACAAGCTGGAGGT-3′; and(SEQ ID NO: 15)5′-GTAGTTGTGCTGATGT-3′,and, wherein the oligomer inhibits Myc expression in a cell or tissue. |
| 地址 |
Piscataway NJ US |
