| 发明名称 |
LONG-LIVED POLYNUCLEOTIDE MOLECULES |
| 摘要 |
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules. |
| 申请公布号 |
US2016024181(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201414774719 |
申请日期 |
2014.03.13 |
| 申请人 |
MODERNA THERAPEUTICS, INC. |
发明人 |
Hoge Stephen G.;Huang Eric Yi-Chun;Chakraborty Tirtha;Elbashir Sayda M. |
| 分类号 |
C07K14/76;C07K14/535;C07K16/00;C07K14/765;C07K14/61;C07K14/605;C07K14/59;C07K14/50 |
主分类号 |
C07K14/76 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated codon optimized mRNA, wherein said mRNA comprising a nucleic acid sequence encoding
(a) a polypeptide of interest; and (b) a first longevity enhancing sequence. |
| 地址 |
Cambridge MA US |
