NOVEL COMPOUNDS

摘要

Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the production of sphingolipids. Suitable sphingolipids, include, but not limited to, sphingosine and compounds incorporating sphingosine or that may use sphingosine as an intermediate or a starting material in their synthesis (including, but not limited to, sphingosine-1-P, ceramide, gangliosides and sphigomyelin). In one contemplated use, compounds of the general formula I and II are useful in the production of sphingosine. In another contemplated use, compounds of the general formula I and II are useful in the production of a sphingofugin. Methods of manufacturing each of the above compounds are also provided.;

主权项

1. A compound of the general formula I: wherein: A is a ketone (═O) or A is R5 and R6; ---- represents an optional double bond; R1 is a substituted or unsubstituted alkyl group or, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocycle or a substituted or unsubstituted heterocycloalkyl, or (CH2)n—R8; R2 is H, substituted or unsubstituted alkyl group or, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group benzyl, or (CH2)p—R9; R3 is a protecting group; R4 is H, a substituted or unsubstituted alkyl, a substituted or unsubstituted aralalkyl, a substituted or unsubstituted heterocycloalkyl, (CH2)m—OH or a side chain group from any one of the naturally or non-naturally occurring amino acids R5 is H or a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, or a substituted or unsubstituted alkynyl group; R6 is a OH or OR7; R7 is a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, or a substituted or unsubstituted alkynyl group; R8 and R9 are each independently selected from a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl a substituted or unsubstituted heterocycle or a substituted or unsubstituted heterocycloalkyl; and m, n and p are each integers independently selected from 0-10.