USE OF NKG2D INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES AND METABOLIC DISEASES SUCH AS TYPE 2 DIABETES

摘要

PROBLEM TO BE SOLVED: To provide: methods, compositions and kits for treating and detecting type 2 diabetes and/or conditions that may be regulated or normalized via inhibition of NKG2D, such as cardiovascular diseases; and effective methods for prediction, prevention and treatment of metabolic dysfunction-associated diseases such as diabetes as well as cardiovascular diseases and disorders.SOLUTION: The present invention relates to the use of a therapeutically effective amount of an agent that blocks the NKG2D ligand binding interaction in a subject for treating conditions that may be regulated or normalized via inhibition of NKG2D, where the conditions are selected from the group consisting of type 2 diabetes, cardiovascular diseases, inflammatory diseases and metabolic dysfunction-associated diseases.