Methods for Doing Business Using Biomarkers

摘要

The present disclosure relates generally to methods for doing business by using one or more biomarkers (e.g., a subject's genetic polymorphisms) to improve the research, development, testing, commercialization and/or marketing of a drug by identifying those subjects for whom the particular drug is likely to be more effective.

主权项

1. A method for conducting a business, said method comprising:
(a) selecting an antibody useful for treatment of a disease or disorder with optimal ADCC activity for a patient group with a FcγRIIIa V/V158, FcγRIIa H/H131; FcγRIIIa V/F158, FcγRIIa H/H131; FcγRIIIa F/F158, FcγRIIa H/H131; FcγRIIIa V/V158, FcγRIIa H/R131; FcγRIIIa V/V158, FcγRIIa R/R131; FcγRIIIa V/F158, FcγRIIa R/R131; FcγRIIIa F/F158, FcγRIIa R/R131; FcγRIIIa V/F158, FcγRIIa H/R131; or a FcγRIIIa F/F158, FcγRIIa H/R131 genotype; and (b) marketing the antibody to health care providers or health care consumers for administration to the patient group.