| 发明名称 |
DEREPRESSION OF IMMUNITY IN ONCOLOGICAL AND VIROLOGICAL CONDITIONS BY HIGH MOBILITY GROUP BOX 1 DERIVED PEPTIDES |
| 摘要 |
Disclosed are compositions of peptides derived from the High Mobility Group Box 1 (HMGB1) protein that are useful in suppressing inhibitory activity of T regulatory cells in conditions of cancer and virus infections. Specifically, this application provides means of derepressing immunity in a state of immune suppression through significantly decreasing the number and/or activity of T regulatory cells. |
| 申请公布号 |
US2016022761(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201514807766 |
申请日期 |
2015.07.23 |
| 申请人 |
Wagner Samuel C.;Ichim Thomas E.;Theofilopoulos Dimitri N.;Kim Andy J. |
发明人 |
Wagner Samuel C.;Ichim Thomas E.;Theofilopoulos Dimitri N.;Kim Andy J. |
| 分类号 |
A61K38/08 |
主分类号 |
A61K38/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting T regulatory cell activity comprising administering a peptide consisting of the amino acid sequence SAFFLFCSE. |
| 地址 |
San Diego CA US |
