发明名称 |
NOVEL FORMULA OF IRON BASED NANOCOMPOSITES FOR RAPID AND EFFICIENT TREATMENT OF IRON DEFICIENCY ANEMIA |
摘要 |
New formulas of Iron oxides nanoparticles capped with a mixture of multivitamins such as folic acid, Nicotinic acid (vitamin B9) and Ascorbic acid (vitamin C) has been developed for the rapid and efficient treatment of life threatening iron-deficiency anemia. Small single dose of iron oxides-multivitamin nano-composite as low as 8.3 mg elemental iron per does is sufficient to increase the hemoglobin level from 4.4 g/dl up to 14.6 g/dl within only four days after administration. The multivitamin which used in this nano-composite enhances iron absorption significantly and elevated the concentration of hemoglobin. Two dosage forms of Iron nano-composites have been developed, gel capsules and aqueous solution for oral administration. Animal trials studies reveal that introducing single dose of Iron Oxide-vitamin nano-composites containing 8.6 mg elemental iron per kg rat body weight is sufficient to correct the hemoglobin level and cure Anemia via oral administration. |
申请公布号 |
US2016022733(A1) |
申请公布日期 |
2016.01.28 |
申请号 |
US201314772648 |
申请日期 |
2013.10.29 |
申请人 |
MAHMOUD Mona Bakr Mohamed;HELMY Sherine Hassan Abbas;NANOTECH FOR PHOTOELECTRONICS RESEARCH ;EUROPEAN EGYPTIAN PHARMACEUTICAL INDUSTRIES (EEPI) |
发明人 |
MAHMOUD Mona Bakr Mohamed;HELMY Sherine Hassan Abbas |
分类号 |
A61K33/26;A61K9/48;A61K31/375;A61K9/00;A61K31/519;A61K31/455 |
主分类号 |
A61K33/26 |
代理机构 |
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代理人 |
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主权项 |
1- A novel formulation for Anemia treatment based on Biocompatible iron oxides nano-composites capped with Folic acid, Nicotinic acid and ascorbic acid |
地址 |
US |