| 发明名称 |
PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES |
| 摘要 |
Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and compositions comprising the tetrahydroisoquinolines and other compounds, e.g, intermediates and by-products of the processes described herein. Pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression are also disclosed. |
| 申请公布号 |
US2016022675(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201414774522 |
申请日期 |
2014.03.12 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
GONZALEZ-BOBES Francisco;CONLON David Alan;LOBBEN Paul C.;BURT Justin Lockheart;ENGSTROM Joshua;WEI Carolyn S.;ZHU Jason J.;FAN Yu |
| 分类号 |
A61K31/501;A61K9/20;A61K9/48;C07D217/04 |
主分类号 |
A61K31/501 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a compound having the following formula: and a compound having the following formula: said Compound 2 present in an amount of from about 1 ppm to less than 1.0 wt % based on the weight of Compound 1. |
| 地址 |
Princeton NJ US |
