| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of raising an immune response against a pathogen of Mycobacterium spp.SOLUTION: The method comprises administering (i) one or more first immunogenic polypeptides derived from the pathogen; (ii) one or more adenoviral vectors comprising one or more heterologous polynucleotides encoding one or more second immunogenic polypeptides derived from the pathogen; and (iii) an adjuvant; where the one or more first immunogenic polypeptides, the one or more adenoviral vectors and the adjuvant are administered concomitantly. The invention also relates to vaccines, pharmaceutical compositions, kits and uses employing the polypeptides, the adenoviral vectors and the adjuvant. |
