FMRI BIOMARKER OF NEURODEGENERATIVE DISEASE

摘要

Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.

主权项

1. A method of identifying a subject with an early, asymptomatic stage of a neurodegenerative disease comprising:
a. selecting a subject in need of screening for the early, asymptomatic stage of a neurodegenerative disease; b. placing the subject in an MRI machine; c. acquiring fMRI data from the subject, optionally, while the subject performs an activation task; and d. calculating a measure of local regional heterogeneity (Hcorr) in one or more brain regions, wherein Hcorr is calculated using a computer readable medium including program instructions for calculating Hcorr, and wherein an decrease in Hcorr as compared to Hcorr from a control subject is indicative of a subject with an early, asymptomatic stage of a neurodegenerative disease.