| 发明名称 |
COMPOSITIONS AND METHODS FOR PREDICTING AGE OF ONSET OF A LYSOSOMAL STORAGE DISEASE OR A DISEASE ASSOCIATED WITH A LYSOSOMAL DEFECT |
| 摘要 |
The present invention features diagnostic compositions and methods for predicting the age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect in subject. |
| 申请公布号 |
US2016025712(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201414776440 |
申请日期 |
2014.03.14 |
| 申请人 |
The United States of America, as represented by th e Secretary, Department of Health & Human Service |
发明人 |
Pavan William J.;Rodriguez Jorge L.;Larson Denise M.;Porter, III Forbes D. |
| 分类号 |
G01N33/52;G01N33/58 |
主分类号 |
G01N33/52 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of predicting the age of disease onset in a subject having a lysosomal storage disease or a disease associated with a lysosomal defect, the method comprising
(a) detecting fluorescence in a cell sample of the subject before and after contacting the cell with a detectable probe that accumulates in acidic cellular compartments; and (b) calculating the fold-change in fluorescence and comparing it to a reference, wherein the fold-change in fluorescence is indicative of the age of lysosomal storage disease onset or onset of a disease associated with a lysosomal defect. |
| 地址 |
Rockville MD US |
