发明名称 |
ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF |
摘要 |
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing. |
申请公布号 |
US2016024171(A1) |
申请公布日期 |
2016.01.28 |
申请号 |
US201514878286 |
申请日期 |
2015.10.08 |
申请人 |
Moderna Therapeutics, Inc. |
发明人 |
Schrum Jason P.;Bancel Stephane;Afeyan Noubar B.;Ejebe Kenechi |
分类号 |
C07K14/685 |
主分类号 |
C07K14/685 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical formulation comprising:
i) an effective amount of a messenger ribonucleic acid (mRNA) sequence encoding a melanocyte-stimulating hormone polypeptide, wherein the mRNA sequence is at least 90% identical to the sequence of SEQ ID NO: 19; and ii) a pharmaceutically acceptable carrier, wherein the formulation is suitable for repeated administration to a mammalian subject in need thereof. |
地址 |
Cambridge MA US |