发明名称 |
SORTASE SYNTHESIZED CHIMERIC ANTIGEN RECEPTORS |
摘要 |
Sortase molecules and methods described herein allow for the construction of a CAR or CAR member, e.g., in situ, on a CARX, e.g., CART, cell. For example, sortase mediated transfer of an antigen binding domain, e.g., a scFv, onto a CAR member having a sortase acceptor motif in place of an antigen binding domain can provide for a complete CAR member on a cell wherein the cell does not comprise nucleic acid that encodes the complete CAR member. |
申请公布号 |
WO2016014553(A1) |
申请公布日期 |
2016.01.28 |
申请号 |
WO2015US41363 |
申请日期 |
2015.07.21 |
申请人 |
NOVARTIS AG;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;BROGDON, JENNIFER;GUIMARAES, CARLA;HASTEWELL, JOHN;LOEW, ANDREAS |
发明人 |
BROGDON, JENNIFER;GUIMARAES, CARLA;HASTEWELL, JOHN;LOEW, ANDREAS |
分类号 |
C07K19/00;C12N9/16;C12N9/52;C12N15/52;C12N15/62;C12N15/63;C12N15/87 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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