发明名称 |
BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND |
摘要 |
This invention relates to a bicyclic nitrogen-containing aromatic heterocyclic amide compound of formula (I), or a salt thereof, which has excellent Complex 1 inhibitory effect and AMPK activating effect, and which is useful as a therapeutic drug for breast cancer. This compound has a cell growth inhibitory effect on a human PIK3CA mutation-positive breast cancer cell line not expressing MCT4 and on a human breast cancer cell line not expressing MCT4 and not having a PIK3CA mutation, and exhibits antitumor action in human PIK3CA mutation-positive breast cancer cell line MDA-MB-453 cell tumor-bearing mice not expressing MCT4. |
申请公布号 |
SG11201510125W(A) |
申请公布日期 |
2016.01.28 |
申请号 |
SG11201510125W |
申请日期 |
2014.06.09 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
OHNUKI, KEI;AZAMI, HIDENORI;SAWADA, YUKI;SHIN, TAKASHI;KURAMOTO, KAZUYUKI;KIKUCHI, SHIGETOSHI;SAITO, TOMOYUKI;HAMAGUCHI, HISAO;NAGASHIMA, TAKEYUKI |
分类号 |
C07D215/48;A61K31/496;A61K31/497;A61P15/14;A61P35/00;C07D235/30;C07D401/04;C07D401/12;C07D401/14;C07D405/14;C07D413/14;C07D471/04;C07D471/14 |
主分类号 |
C07D215/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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