发明名称 |
HUMAN MONOCLONAL ANTIBODIES TO GANGLIOSIDE GD2 |
摘要 |
The present invention provides compositions for the production of an antibody or functional fragment thereof directed against disialoganglioside-GD2. The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to GD2. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof. |
申请公布号 |
WO2015187811(A3) |
申请公布日期 |
2016.01.28 |
申请号 |
WO2015US33954 |
申请日期 |
2015.06.03 |
申请人 |
MABVAX THERAPEUTICS, INC. |
发明人 |
SCHOLZ, WOLFGANG;SAWADA, RITSUKO |
分类号 |
A61K39/395;A61K47/48;C07K16/30 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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