发明名称 |
RADIOPROTECTANTS TARGETING THROMBOSPONDIN-1 AND CD47 |
摘要 |
Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation exposure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment. |
申请公布号 |
EP2340034(B1) |
申请公布日期 |
2016.01.27 |
申请号 |
EP20090791202 |
申请日期 |
2009.08.05 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
ISENBERG, JEFFREY, S.;ROBERTS, DAVID, D.;MAXHIMER, JUSTIN |
分类号 |
A61K38/39;A61K39/00;A61N5/10;A61P39/00;C07K14/705;C07K14/78;C07K16/18;C07K16/28;C12N15/113 |
主分类号 |
A61K38/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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