发明名称 |
METHOD FOR POSITIONING, IN CYTOPLASM, ANTIBODY HAVING COMPLETE IMMUNOGLOBULIN FORM BY PENETRATING ANTIBODY THROUGH CELL MEMBRANE, AND USE FOR SAME |
摘要 |
The present invention relates to a method for positioning, in a cytoplasm, an antibody having a complete immunoglobulin form, by means of active cell penetration. In addition, the present invention relates to a light chain variable region (VL) that induces the active penetration of a cell membrane of a living cell by an antibody having a complete immunoglobulin form and the positioning of the antibody in the cytoplasm, and an antibody comprising same. Also, the present invention relates to a bioactive molecule fused to the antibody. Also, the present invention relates to a composition for preventing, treating or diagnosing cancer, comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes the light chain variable region and the antibody. The present invention also relates to a method for preparing an antibody that is made to penetrate through to the inside of a cell and positioned in the cytoplasm. |
申请公布号 |
WO2016013870(A1) |
申请公布日期 |
2016.01.28 |
申请号 |
WO2015KR07626 |
申请日期 |
2015.07.22 |
申请人 |
AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;MEDICINAL BIOCONVERGENCE RESEARCH CENTER |
发明人 |
KIM, YONG SUNG;CHOI, DONG KI;SHIN, SEUNG MIN;KIM, SUNG HOON |
分类号 |
C07K16/46;A61K39/395;A61K47/48;A61P35/00;C07K16/32 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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