发明名称 |
COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF FOR TREATING CANCER |
摘要 |
A recombinant polypeptide comprising (i) a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA) protein encoded by a nucleotide sequence selected from SEQ ID NOs: 21-23, or a polypeptide having greater than 97% sequence identity thereto, and (ii) a PEST sequence from Listeria, or a recombinant Listeria comprising said recombinant polypeptide, for use in inducing an immune response to a cancer or tumor that does not express HMW-MAA, for use in delaying the progression of a cancer or tumor that does not express HMW-MAA, or for use in treating a cancer or tumor that does not express HMW-MAA. |
申请公布号 |
EP2977456(A1) |
申请公布日期 |
2016.01.27 |
申请号 |
EP20150172620 |
申请日期 |
2007.08.15 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
FERRONE, SOLDANO;PATERSON, YVONNE;MACIAG, PAULO |
分类号 |
C12N15/63;A61K39/00;C12N15/87;C12N15/90;C12P21/06 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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