发明名称 |
ENGINEERED CONFORMATIONALLY-STABILIZED PROTEINS |
摘要 |
Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner. |
申请公布号 |
EP2825549(A4) |
申请公布日期 |
2016.01.27 |
申请号 |
EP20120871585 |
申请日期 |
2012.06.19 |
申请人 |
F. HOFFMANN-LA ROCHE SA |
发明人 |
CORN, JACOB, E.;ZHANG, YINGNAN;PHILLIPS, AARON, H. |
分类号 |
C07K14/00;A61K38/16;A61P35/00;G01N33/68 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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