| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to conjugates, in particular presented is nicotine hapten-carrier of formula (III):W represents -O- and is in position 5 of pyridine ring; -(spacer)- represents C-Calkylene group, C-Ccycloalkylene group or C-Calkylene group, interrupted by 1-4 oxygen atoms and possibly interrupted by group -N(H)C(O)-; X* represents -NH- or -S-; m stands for 1; n stands for integer number from 1 to 1000; and Y represents possibly modified carrier protein, selected from bacterial anatoxins, immunogenic substances, viruses, virus-like particles, protein complexes, proteins, polypeptides, liposomes and immunostimulating complexes, which can be used for preparation of vaccines for treatment and/or prevention of nicotine dependence.EFFECT: obtaining compounds which can be used for preparation of vaccines for treatment and/or prevention of nicotine dependence.8 cl, 23 dwg, 7 tbl, 22 ex |
