摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of structural formula (I)possessing inhibitory activity on the TAM family of receptor tyrosine kinases (RTKs). In formula (I) A represents C-R; B represents C-R, N; R, Rare independently specified in -H, -F, -Cl, -Br, -I, -OH, -NH, -OCH, -OCH, -OCH, -OCH(CH), -NO, -CHO, -COCH, -COCH, -COCH, -O-cyclo-CH, -OCH-cyclo-CH, -O-CH-cyclo-CH, -OCF, -OCF, -CHF, -CHF, -CF, -CHCl, -CHBr, -CHI, -CH-CHF, -CH-CHF, -CH-CF, -CH-CHCl, -CH-CHBr, -CH-CHI, cyclo-CH, -CH-cyclo-CH, -CH, -CH, -CH, -CH(CH), -CH, -CH-CH(CH), -CH(CH)-CH, -C(CH), -CH=CH, -CH-CH=CH, -C(CH)=CH, -CH=CH-CH; Rare Rare independently specified in -O-R, -O-CRR-R, -O-CRR-CRR-R, -O-CRR-CRR-CRR-R, -O-CRR-CRR-CRR-CRR-R; Rand Rrepresent -H; R, R, which can be identical or different from each other, represent -H, -F, -Cl, -Br, -I, -CN, -NO, -CH, -CH, -CH, -CH(CH), cyclo-CH, -CH-cyclo-CH, -OCH; Rrepresents -H. The radical values D, R, R, R, RRare presented in the patent claim. The invention also refers to a pharmaceutical composition containing the above compound.EFFECT: producing the compounds possessing the inhibitory activity on the TAM family of receptor tyrosine kinases (RTKs).14 cl, 3 tbl, 106 ex |