| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to compound of structural formula (1), which possesses inhibiting activity with respect to rotamase «FKBP12». In formulaRrepresents formulaeorX represents -(CH)-X-(CH)-; Xrepresents bond, -O-, -NRC(=O)-, -C(=O)NR-, -NRS(=O)- or -S(=O)NR-; R, R, Rand R, each can be similar or different and represent hydrogen atom or Calkyl group; m and n, each, can be similar or different and represent integer number 0-3; Rrepresents phenyl group, pyridyl group, pyridazyl group, pyrimidyl group or pyrazinyl group. Values of ring A radical and substituents of Rradical are disclosed in invention formula. Invention also relates to pharmaceutical preparation, which contains claimed compound, and to medication for prevention of treatment of alopecia.EFFECT: increase of treatment efficiency.12 cl, 3 dwg, 1 tbl, 24 ex |
