Genes associated with posttraumatic-stress disorder (PTSD)

摘要

The present invention relates to a method of identifying a predisposition for developing posttraumatic stress disorder (PTSD) in a subject comprising assessing in a sample obtained from said subject the expression level of one or more genes selected from the FK506 binding protein 5 (FKBP5) gene, the signal transducer and activator of transcription (STAT5B) gene and the nuclear factor I/A (NFIA) gene, wherein a decrease in the expression level of said one or more genes as compared to the expression level of the corresponding gene(s) of a control is indicative of a predisposition for developing PTSD. Further, the invention relates to a method of identifying a compound capable of preventing or treating PTSD or capable of serving as a lead compound for developing a compound capable of preventing or treating PTSD and also to a method of selecting a therapy to prevent or treat PTSD.

主权项

1. A method for diagnosing and treating a human subject with a predisposition to post-traumatic stress disorder (PTSD), comprising:
i) detecting in a blood sample obtained from the human subject a test expression level of FK506 binding protein (FKBP5) gene mRNA; ii) comparing the test expression level to a mean expression level of FK506 binding protein gene mRNA in control blood samples from a population not predisposed to PTSD and detecting that the test expression level is decreased compared to the mean expression level; iii) correlating the detected test expression level with the presence of a predisposition to PTSD in the subject; and iv) applying to the subject a therapy to treat or prevent PTSD selected from psychopharmacological medication and/or psychotherapy.