Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity

摘要

Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.

主权项

1. An anti-microbial composition comprising at least one Gramicidin A peptide analog or derivative having reduced cytotoxicity and increased solubility relative to wild-type Gramicidin A wherein the wild-type Gramicidin A comprises the amino acid sequence of SEQ ID NO: 2, and wherein the at least one Gramicidin A peptide analog or derivative comprises the amino acid sequence of SEQ ID NO: 2, wherein one of the d-Leucine amino acids at positions 10 or 14 of the SEQ ID NO: 2 have been replaced or substituted with a cationic residue.