发明名称 |
Phosphate ester compound of hydroxy acid substituted phenol ester, preparation method and medical use thereof |
摘要 |
Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y═C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.; |
申请公布号 |
US9243009(B2) |
申请公布日期 |
2016.01.26 |
申请号 |
US201013702204 |
申请日期 |
2010.10.13 |
申请人 |
West China Hospital, Sichuan University;Yichang Humanwell Pharmaceutical Co., Ltd. |
发明人 |
Zhang Wensheng;Yang Jun;Liu Jin |
分类号 |
C07F9/09 |
主分类号 |
C07F9/09 |
代理机构 |
Cesari and McKenna, LLP |
代理人 |
Cesari and McKenna, LLP |
主权项 |
1. A phosphate ester compound of hydroxy acid substituted phenol ester represented by the following structure formula (I): wherein Y is a C1-4 straight saturated carbon chain optionally substituted with methyl, ethyl, cyclopropyl, hydroxy, sulfhydryl, amino, or a substituted amino group, M1 and M2 are the same or independently represent hydrogen, alkali metal ion, protonated amino or protonated amino acid. |
地址 |
Sichuan CN |