Antibodies for botulinum neurotoxins

摘要

The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

主权项

1. An isolated antibody, or antigen-binding fragment thereof, that competes for binding with, or specifically binds an epitope of a Botulinum neurotoxin that is specifically bound by, an antibody comprising:
a) a VH CDR1 comprising the amino acid sequence of residues 31-35 of SEQ ID NO:68; b) a VH CDR2 comprising the amino acid sequence of residues 50-66 of SEQ ID NO:68; c) a VH CDR3 comprising the amino acid sequence of residues 99-114 of SEQ ID NO:68; d) a VL CDR1 comprising the amino acid sequence of residues 24-34 of SEQ ID NO:205; e) a VL CDR2 comprising the amino acid sequence of residues 50-56 of SEQ ID NO:205; and f) a VL CDR3 comprising the amino acid sequence of residues 89-97 of SEQ ID NO:205.