Methods and compositions related to immunogenic fibrils

摘要

Embodiments of the invention are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any adjuvant.

主权项

1. An immunogenic composition comprising a peptide fibril coupled to a plurality of antigens, wherein the peptide fibril comprises a plurality of self-assembling peptides, wherein the self-assembling peptide comprises an amino acid sequence of QQKFQFQFEQQ (SEQ ID NO: 1), and wherein an antigen is covalently coupled to a terminus of a self-assembling peptide.