| 主权项 |
1. An extracellular matrix (ECM) valve conduit for regenerating a semi-lunar valve within a heart of a subject, comprising:
a tubular valve construct comprising an acellular extracellular matrix (ECM) material, said tubular valve construct having a longitudinal axis and an outer wall, said tubular valve construct further comprising a lumen, an inlet portion and an outlet portion, said inlet portion comprising an inner layer and an outer layer, said inner layer of said inlet portion comprising a top edge, said outlet portion comprising an inner layer and outer layer, said outer layers of said inlet and outlet portions defining said outer wall of said tubular valve construct, said outlet portion defining an outlet in fluid communication with said lumen of said tubular valve construct, said inlet portion defining an inlet in fluid communication with the lumen of said tubular valve construct, said inner layer being positioned within said lumen of said tubular valve conduit, said inner layer of said outlet portion being inwardly reflected within said lumen of said tubular valve construct, wherein said inner layer top edge is disposed proximate said tubular valve construct inlet, said inner layer of said outlet portion being attached to said outer layer solely at first, second, third and fourth attachment points adjacent said inner layer top edge, said first, seconds third and fourth attachment points being equally spaced along an outer circumference of said tubular valve conduit and positioned on a common plane that is perpendicular to said tubular valve construct longitudinal axis, wherein said inner and outer layers are not secured to each other proximate said inlet, wherein a commissure-promoting portion is formed on said inner layer of said inlet portion of said tubular valve construct and a sinus-promoting portion is formed on said outer wall of said tubular valve construct, and wherein after implantation into the heart of the subject, the valve conduit acts to regenerate leaflets of the semi-lunar valve. |
