Anti-human norovirus GII antibody

摘要

An anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2):
P-X1-X2-P-G-E  (1) (SEQ ID NO: 2)X3-X4-X5-F-Y-X6-L-X7-P-X8  (2) (SEQ ID NO: 3)
(wherein, X1 represents L, V, N, T, S, M, or R; X2 represents F, Y, or M; X3 represents V or G; X4 represents N or S; X5 represents Q, P, or S; X6 represents S, T, or I; X7 represents A or S; and X8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.

主权项

1. An anti-human-norovirus GII antibody that binds to epitopes in an amino acid region represented by (i), (ii), and (iii):
(i) an epitope in an amino acid region of at least one amino acid sequence of formula (1):
P-X1-X2-P-G-E  (1) (SEQ ID NO: 2) wherein
X1 represents L, V, N, T, S, M, or R;X2 represents F, Y, S or M; (ii) an epitope in an amino acid region of at least one amino acid sequence of formula (2)
X3-X4-X5-F-Y-X6-L-X7-P-X8  (2) (SEQ ID NO: 3) wherein
X3 represents V or G;X4 represents N or S;X5 represents Q, P, or S;X6 represents S, T, or I;X7 represents A or S; andX8 represents M or V; and (iii) an epitope in an amino acid region comprising amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or comprising an amino acid corresponding to amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid region represented by (i), (ii), and (iii) is present in a P domain of a capsid structural protein of a human norovirus GII.