| 发明名称 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | ||
| 摘要 | Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability. | ||
| 申请公布号 | US9242957(B2) | 申请公布日期 | 2016.01.26 |
| 申请号 | US201414285927 | 申请日期 | 2014.05.23 |
| 申请人 | Northwestern University | 发明人 | Silverman Richard B.;Huang He;Jing Qing |
| 分类号 | C07D333/38;C07D409/12 | 主分类号 | C07D333/38 |
| 代理机构 | Reinhart Boerner Van Deuren s.c. | 代理人 | Reinhart Boerner Van Deuren s.c. |
| 主权项 | 1. A compound of a formulawherein L is selected from a covalent bond and divalent CH═CH, CH2CH2, OCH2CH(OH), O(CH2)2O, O(CH2)3O, (CH2)2NH, (CH2)2NHCH2, CH2CH(CH2NH2)CH2CH2, CH2CH(CH2NH2)NHCH2 and OCH(CH2NH2)CH2O moieties; or a salt thereof. | ||
| 地址 | Evanston IL US | ||