Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof

摘要

The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

主权项

1. A method of maintaining homeostasis in a human subject in need of a surgery comprising administering to the subject multiple doses of about 10 IU/kg to about 50 IU/kg of a long-acting Factor VIII (“FVIII”) polypeptide at a dosing interval of 12 hours or longer between two doses,
wherein the long-acting FVIII polypeptide is a FVIIIFc monomer dimer hybrid comprising a FVIII portion and two Fc portions, wherein one of the Fc portions is fused to the C-terminus of the light chain of the FVIII portion.