Substituted pyridazine carboxamide compounds as kinase inhibitor compounds

摘要

The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

主权项

1. A compound of formula I:or a salt thereof; wherein:
R1, R2, R3, and R4 each are independently H, alkyl, or Z1; R6 is an unsaturated heterocyclyl, wherein R6 is optionally substituted by 1- 3 groups independently selected from alkyl, cycloalkyl, heterocyclyl, alkoxy, hydroxyalkyl, and Z1; Each Z1 is halogen, CN, NO2, OR15, SR15, S(O)2OR15, NR15R16, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR15, C(O)NR15R16, OC(O)NR15R16, NR15C(O)NR15R16, C(NR16)NR15R16, NR15C(NR16)NR15R16,S(O)2NR15R16, R17,C(O)R17, NR15C(O)R17, S(O)R17, S(O)2R17, R16, oxo, C(O)R16, C(O)(CH2)nOH, (CH2)n OR15, (CH2)nC(O)NR15R16,NR15S(O)2R17, where each n is independently 0-6; Each R15 is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl; Each R16 is independently hydrogen, alkenyl, alkynyl,C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl; and Each R17 is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl.