Chemoembolisation

摘要

A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.

主权项

1. A composition comprising substantially dry microspheres having a matrix of cross-linked water-swellable water-insoluble polymer comprising poly (vinyl alcohol) and, a water-soluble therapeutic agent which is not covalently attached to the matrix, wherein the polymer has an overall anionic charge at a pH in the range 6 to 8, wherein the anionic charge is at a level of 1 to 10 meq/g, wherein themicrospheres, when swollen to equilibrium in water, have particle sizes in the range 40-1500 μm, and wherein the therapeutic agent is an anthracycline compound having at least one amine group.