发明名称 |
Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof |
摘要 |
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against herpes virus using the vaccines that are provided. |
申请公布号 |
US9243041(B2) |
申请公布日期 |
2016.01.26 |
申请号 |
US201213982457 |
申请日期 |
2012.01.31 |
申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Weiner David B;Shedlock Devon J |
分类号 |
A61K39/245;A61K39/25;A61K39/12;C07K14/005;C07K14/045;C12N15/38;A61K39/00 |
主分类号 |
A61K39/245 |
代理机构 |
Riverside Law LLP |
代理人 |
Riverside Law LLP |
主权项 |
1. A nucleic acid molecule comprising a coding sequence for a human cytomegalovirus (HCMV) antigen encoding one or more proteins selected from the group consisting of:
a protein that is at least 95% identical to SEQ ID NO:2 or comprises SEQ ID NO:2; a protein that is at least 95% identical to SEQ ID NO:4 or comprises SEQ ID NO:4; a protein that is at least 95% identical to SEQ ID NO:6 or comprises SEQ ID NO:6; a protein that comprises SEQ ID NO:8; a protein that is at least 95% identical to SEQ ID NO:10 or comprises SEQ ID NO:10; a protein that is at least 95% identical to SEQ ID NO:12 or comprises SEQ ID NO:12; a protein that is at least 97% identical to SEQ ID NO:14 or comprises SEQ ID NO:14; a protein that is at least 97% identical to SEQ ID NO:16 or comprises SEQ ID NO:16; a protein that is at least 95% identical to SEQ ID NO:18 or comprises SEQ ID NO:18; and a protein that is at least 98% identical to SEQ ID NO:20 or comprises SEQ ID NO:20. |
地址 |
Philadelphia PA US |