发明名称 Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
摘要 Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against herpes virus using the vaccines that are provided.
申请公布号 US9243041(B2) 申请公布日期 2016.01.26
申请号 US201213982457 申请日期 2012.01.31
申请人 The Trustees of the University of Pennsylvania 发明人 Weiner David B;Shedlock Devon J
分类号 A61K39/245;A61K39/25;A61K39/12;C07K14/005;C07K14/045;C12N15/38;A61K39/00 主分类号 A61K39/245
代理机构 Riverside Law LLP 代理人 Riverside Law LLP
主权项 1. A nucleic acid molecule comprising a coding sequence for a human cytomegalovirus (HCMV) antigen encoding one or more proteins selected from the group consisting of: a protein that is at least 95% identical to SEQ ID NO:2 or comprises SEQ ID NO:2; a protein that is at least 95% identical to SEQ ID NO:4 or comprises SEQ ID NO:4; a protein that is at least 95% identical to SEQ ID NO:6 or comprises SEQ ID NO:6; a protein that comprises SEQ ID NO:8; a protein that is at least 95% identical to SEQ ID NO:10 or comprises SEQ ID NO:10; a protein that is at least 95% identical to SEQ ID NO:12 or comprises SEQ ID NO:12; a protein that is at least 97% identical to SEQ ID NO:14 or comprises SEQ ID NO:14; a protein that is at least 97% identical to SEQ ID NO:16 or comprises SEQ ID NO:16; a protein that is at least 95% identical to SEQ ID NO:18 or comprises SEQ ID NO:18; and a protein that is at least 98% identical to SEQ ID NO:20 or comprises SEQ ID NO:20.
地址 Philadelphia PA US