| 主权项 |
1. A compound having the structure of formula I: or pharmaceutically acceptable salt thereof, wherein:
Y is selected from the group consisting of —S—, —O—, and —CH2—;n is 0-3;G is selected from the group consisting of —C(O)NR1R2; —C(O)NR1OR2; —NR1C(O)R2; —NR1C(O)NR2R3; —NR1C(O)OR2; —NR1S(O)2R2; —NR1S(O)2NR2R3; —C(═NR1)R2; —C(═NR1)NR2R3; —NR1CR2(═NR3); —NR1C(═NR2)NR3R4; aryl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR1, —NR1R2, halogen, —C(O)NR1R2, and —NR1C(O)R2; heteroaryl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR1, —NR1R2, halogen, —C(O)NR1R2, and —NR1C(O)R2; and heterocyclyl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR1, —NR1R2, halogen, —C(O)NR1R2, and —NR1C(O)R2;J, L, and M are each independently selected from the group consisting of CR7 and N;R is selected from a group consisting of —H, —C1-9alkyl, —CR5R6OC(O)C1-9alkyl, —CR5R6OC(O)OC1-9alkyl, and R1, R2, R3, R4, R5 and R6 are each independently selected from —H and —C1-4alkyl; andR7 is selected from the group consisting of —H, —C1-4alkyl, —OH, —OC1-4alkyl, and halogen. |
