Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit

摘要

The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

主权项

1. A method comprising the steps of:
(a) providing cognitive training to an animal during rehabilitation of said animal from a trauma-dependent loss of cognitive function under conditions sufficient to produce an improvement in performance by said animal of a cognitive task whose deficit is associated with said trauma-dependent loss of cognitive function; (b) administering to said animal in conjunction with said cognitive training an augmenting agent that enhances CREB pathway function; (c) repeating said providing and said administering of steps (a) and (b) one or more times; and (d) reducing the number of training sessions sufficient to produce said improvement in performance of said task relative to the improvement in performance of said task produced by cognitive training alone; wherein said trauma-dependent loss of cognitive function is associated with a cerebrovascular disorder; and wherein said augmenting agent is one or more compounds of Formula I: wherein “Me” means “methyl” and “cPent” means “cyclopentyl” and enantiomers and mixtures thereof.