uso de modulinas solúveis em fenol no desenvolvimento de vacinas

摘要

The invention relates to methods for increasing immunogenicity of an antigenic peptide by means of its covalent coupling to a modulin derived peptide (PSM, phenol soluble modulin). In particular, the binding of PSM±, PSM³ and PSM´ peptides to an antigen (from a pathogen or a tumor associated protein) increases the capacity of the antigen to activate an immune response in vivo. Thus, the PSM±, PSM³ and PSM´ peptides bound to these antigens may be used in the development of vaccines for preventing or treating infectious diseases or cancer