Method for producing implants with an ultrahydrophilic surface

摘要

The present invention concerns a process for the production of implants with an ultrahydrophilic surface as well as the implants produced in that way and also processes for the production of loaded, so-called bioactive implant surfaces of metallic or ceramic materials, which are used for implants such as artificial bones, joints, dental implants or also very small implants, for example what are referred to as stents, as well as implants which are further produced in accordance with the processes and which as so-called “delivery devices” allow controlled liberation, for example by way of dissociation, of the bioactive molecules from the implant materials.

主权项

1. A process for the production of an implant with an ultrahydrophilic surface with dynamic contact angles from 0° to 10° upon wetting of the surface of the implant with water, comprising the steps of:
(a) providing a metal implant having a surface made from a material selected from the group consisting of a metal, a metal alloy, and a combination of a ceramic material with a metal or metal alloy; (b) immersing the metal implant in chromosulphuric acid having a density of more than 1.40 g/cm3, at a temperature of above 200° C., for a period of from 10 to 90 minutes; and (c) directly after removal, quenching the metal implant by immersion in concentrated sulphuric acid at a temperature of 15° to 25° C. and washing the surface of the metal implant with distilled water in a plurality of washing steps.