MiR-33 inhibitors and uses thereof to decrease inflammation

摘要

The inhibition of miRNA miR-33 is shown to promote the polarization of macrophages from an M1 to an M2 phenotype. MiR-33 inhibitors are therefore useful for treating inflammation in subjects. Endogenous microRNAs can be silenced using antagomirs. The miR-33 inhibitor is preferably an antagomir having a single-stranded nucleic acid sequence that is complementary to at least 12 contiguous nucleotides in miR-33 and therefore forms a duplex with miR-33 under physiological conditions.

主权项

1. A method for reducing inflammation comprising administering to a subject with an inflamed tissue comprising M1 macrophages, an inhibitor that specifically targets miR-33 in an amount effective to reduce inflammation in the tissue of the subject.