Methods for treatment of lymphomas with mutations in cell cycle genes

摘要

The present disclosure identifies a novel subtype of follicular lymphoma (FL) characterized by dysregulation of the cyclin/CDK/RB proliferative pathway. This subtype of FL is associated with increased malignancy and mortality, relative to FL which is not associated with cell cycle dysregulation. Accordingly, this disclosure presents novel methods to subtype FL and stratify patient risk by detection of biomarkers associated with RB inactivation. This disclosure further presents novel therapies for the treatment of FL subtyped by inactivation of RB.

主权项

1. A pharmaceutical composition for treating follicular lymphoma, comprising a combination of a sub-optimal dose of a B-cell lymphoma-2 (BCL2) inhibitor selected from ABT-737 or Obatoclax mesvlate, and a sub-optimal dose of the cyclin-dependent kinase (CDK) inhibitor PD-0332991, wherein the combination is effective for the treatment of a patient identified as having retinoblastoma (RB)-inactivated FL.