Compositions and methods for treating cancer

摘要

A method of one or more of, inhibiting motility, migration, dispersal, and metastasis of a cell that expresses an RPTP, which is proteolytically cleaved to form intracellular fragments in the cell includes administering to the cell an amount of an agent effective to inhibit one or more of the catalytic activity and function of the proteolytically cleaved intracellular domain-containing fragments of the RPTP.

主权项

1. A method of inhibiting in a subject one or more of motility, migration, and dispersal of a cancer cell that express PTPμ that is proteolytically cleaved to produce intracellular domain-containing fragments, the method comprising:
administering to the cancer cells in the subject an amount of a therapeutic agent effective to inhibit function of the proteolytically cleaved intracellular domain-containing fragments of PTPμ, the therapeutic agent comprising a polypeptide that has at least 90% sequence identity to the amino acid sequence of a wedge domain of PTPμ.